For those who want to "block" the launcher from communicating entirely—often helpful for older titles or avoiding intrusive updates—you can create an outbound firewall rule.
Newer Ubisoft games (2021–present) layer Denuvo Anti-Tamper on top of VMProtect. As of today, no exists for titles like Avatar: Frontiers of Pandora or Skull and Bones that removes Ubisoft Connect entirely without breaking the game. The few bypasses available are: bypass ubisoft connect full